期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1861, 期 9, 页码 1207-1213出版社
ELSEVIER
DOI: 10.1016/j.bbalip.2016.04.004
关键词
Plants; Acetyl-CoA carboxylase; ACCase; Fatty acid synthesis; BADC; Protein-protein interactions
资金
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1339385] Funding Source: National Science Foundation
The enzyme acetyl-CoA carboxylase (ACCase) catalyzes the committed step of the de novo fatty acid biosynthesis (FAS) pathway by converting acetyl-CoA to malonyl-CoA. Two forms of ACCase exist in nature, a homomeric and heteromic form. The heteromeric form of this enzyme requires four different subunits for activity: biotin carboxylase; biotin carboxyl carrier protein; and alpha- and beta-carboxyltransferases. Heteromeric ACCases (htACCase) can be found in prokaryotes and the plastids of most plants. The plant htACCase is regulated by diverse mechanisms reflected by the biochemical and genetic complexity of this multienzyme complex and the plastid stroma where it resides. In this review we summarize the regulation of the plant htACCase and also describe the structural characteristics of this complex from both prokaryotes and plants. This article is part of a Special Issue entitled: Plant Lipid Biology edited by Kent D. Chapman and Ivo Feussner. (C) 2016 Elsevier B.V. All rights reserved.
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