4.8 Article

An Injectable Conductive Three-Dimensional Elastic Network by Tangled Surgical-Suture Spring for Heart Repair

期刊

ACS NANO
卷 13, 期 12, 页码 14122-14137

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b06761

关键词

biospring of suture; coiled fibers electrode; injectable conductive elastic network; cardiomyocytes' contractile force monitoring myocardial infarction

资金

  1. National Natural Science Foundation of China [31572343, U1601221, 31922043]
  2. Science and Technology Projects of Guangzhou City [201804020035]
  3. Guangdong Province Science and Technology Projects [2017B030314038]
  4. Key Research and Development Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory [2018GZR110104002]
  5. National Science and Engineering Research Council of Canada (NSERC)
  6. NSERC Accelerator Supplemental Award
  7. Canada Foundation for Innovation-Innovation Funds

向作者/读者索取更多资源

Designing scaffolds with persistent elasticity and conductivity to mimic microenvironments becomes a feasible way to repair cardiac tissue. Injectable biomaterials for cardiac tissue engineering have demonstrated the ability to restore cardiac function by preventing ventricular dilation, enhancing angiogenesis, and improving conduction velocity. However, limitations are still among them, such as poor mechanical stability, low conductivity, and complicated procedure. Here, we developed thermal plastic poly(glycolic acid) surgical suture and mussel-inspired conductive particle's adhesion into a highly elastic, conductive spring-like coils. The polypyrrole (PPy)-coated biospring acted as an electrode and then was assembled into a solid-state supercapacitor. After being injected through a syringe needle (0.33 mm inner diameter), the tangled coils formed an elastically conductive three-dimensional (3-D) network to modulate cardiac function. We found that cardiomyocytes (CMs) grew along the spring coils' track with elongated morphologies and formed highly oriented sarcomeres. The biospring enhanced the CMs' maturation in synchronous contraction accompanied by high expressions of cardiac-specific proteins, a-actinin, and connexin 43 (cx43). After the elastic, conductive biosprings were injected into the myocardial infarction (MI) area, the left ventricular fractional shortening was improved by about 12.6% and the infarct size was decreased by about 34%. Interestingly, the spring can be utilized as a sensor to measure the CMs' contractile force, which was 1.57 x 10(-3) +/- 0.26 x 10(-3) mN (similar to 4.1 x 10(6) cells). Accordingly, this study highlights an injectable biospring to form a tangled conductive 3-D network in vivo for MI repair.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据