4.8 Article

Engineering a Biodegradable Multifunctional Antibacterial Bioactive Nanosystem for Enhancing Tumor Photothermo- Chemotherapy and Bone Regeneration

期刊

ACS NANO
卷 14, 期 1, 页码 442-453

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b06145

关键词

bioactive biomaterials; multifunctional nanosystems; photothermal therapy; cancer therapy; bone tissue engineering

资金

  1. National Natural Science Foundation of China [51872224]
  2. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University [2018LHM-KEKT004]
  3. Special Guidance Funds for the Construction of World -class Universities
  4. Characteristic Development in Central Universities [PY3A078]
  5. Fundamental Research Funds for the Central Universities [xzy022019050]

向作者/读者索取更多资源

The simultaneous therapy of tumors and bone defects resulting from tumor surgery is still a challenge in clinical orthopedics. Few nanomaterial systems simultaneously possess multifunctional capacities, including biodegradability, tumor treatment, and enhanced bone regeneration. Herein, we designed a biodegradable monodispersed bioactive glass nanoparticle (BGN) platform with multifunctional properties for enhanced colon cancer photothermo-chemotherapy and bone repair. The mussel-inspired surface assembly with BGN was established as a stable NIR-excited photothermal nanoplatform (BGN@PDA) for ablating tumors. BGN@PDA shows an ultrahigh anticancer drug (DOX) loading with on-demand (pH/NIR-responsive) drug release behavior and antibacterial activity for enhanced tumor chemotherapy (BGN@PDADOX). The growth of colon cancer cells (Hct116 cells) and cervical cancer cells (HeLa cells) was significantly inhibited in vitro, and superior local anticancer efficacy could be achieved by synergic chemo-photothermal therapy in vivo. BGN@PDA underwent a gradual degradation in vivo during 60 days and showed negligible toxic side effects. Meanwhile, BGN@PDA could positively induce the osteogenesis of osteoblasts in vitro and possess excellent in vivo bone repair ability in rat cranial defects. This work presents a distinctive strategy to design a bioactive multifunctional nanoplatform for treating tumor disease-resulted bone tissue regeneration.

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