4.6 Article

Lipid droplets, lipophagy, and beyond

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2015.12.010

关键词

Lipid droplet; Lipid homeostasis; Lipolysis; Lipophagy; Triacylglycerol; Sterol

资金

  1. Academia Sinica
  2. Ministry of Science and Technology, Taiwan [NSC 103-2633-B-001-003, 104-2311-B-001-015-MY3]

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Lipids are essential components for life. Their various structural and physical properties influence diverse cellular processes and, thereby, human health. Lipids are not genetically encoded but are synthesized and modified by complex metabolic pathways, supplying energy, membranes, signaling molecules, and hormones to affect growth, physiology, and response to environmental insults. Lipid homeostasis is crucial, such that excess fatty acids (FAs) can be harmful to cells. To prevent such lipotoxicity, cells convert excess FM into neutral lipids for storage in organelles called lipid droplets (LDs). These organelles do not simply manage lipid storage and metabolism but also are involved in protein quality management, pathogenesis, immune responses, and, potentially, neurodegeneration. In recent years, a major trend in LD biology has centered around the physiology of lipid mobilization via lipophagy of fat stored within LDs. This review summarizes key findings in LD biology and lipophagy, offering novel insights into this rapidly growing field. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim P. Levine and Anant K. Menon. (C) 2015 Elsevier B.V. All rights reserved.

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