期刊
ACS NANO
卷 14, 期 8, 页码 9532-9544出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b05169
关键词
photodynamic therapy; gold nanocluster; type I photochemical mechanism; two photon; in vivo
类别
资金
- National Natural Science Foundation of China [11174089, 11404390, 20973008, 21227803, 11674389]
- Open Project of State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China [2018-MDB-KF-07]
- National Key Research and Development Program of China [2016YFC0800900]
Photodynamic therapy (PDT) is a clinically approved, minimally invasive therapeutic technique that can induce the regression of targeted lesions via generating excess cytotoxic reactive oxygen species. However, due to the limited penetration depth of visible excitation light and the intrinsic hypoxia microenvironment of solid tumors, the efficacy of PDT in the treatment of cancer, especially deep-seated or large tumors, is unsatisfactory. Herein, we developed an efficient in vivo PDT system based on a nanomaterial, dihydrolipoic acid coated gold nanocluster (AuNC@DHLA), that combined the advantages of large penetration depth in tissue, extremely high two-photon (TP) absorption cross section (sigma(2) similar to 10(6) GM), efficient ROS generation, a type I photochemical mechanism, and negligible in vivo toxicity. With AuNC@DHLA as the photosensitizer, highly efficient in vivo TP-PDT has been achieved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据