期刊
ACS NANO
卷 13, 期 11, 页码 13382-13389出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b06780
关键词
nano-antioxidants; cerebral ischemia/reperfusion injury; positron emission tomography; oxidative stress; intrathecal injection
类别
资金
- University of Wisconsin-Madison [P30CA014520]
- National Institutes of Health [P30CA014520]
- National Natural Science Foundation of China [81760417, 81660230, 81871031]
- Science and Technology Program of Jiangxi Province, China [2016ACB21019, 2018ACB20020]
Oxidative stress is one of the important mechanisms in cerebral ischemia/reperfusion (I/R) injury. Antioxidants with high brain accumulation are highly desired to help prevent cerebral I/R injury. Herein, intrathecal injection of polyoxometalate (POM) nano clusters as nano-antioxidants with preferential brain uptake were applied for neuronal protection in cerebral I/R injury. Using powerful positron emission tomography imaging, the uptake of nano-antioxidants in the brain was non-invasively and real-timely monitored. Our results demonstrated that POM nanoclusters rapidly reached the ischemic penumbra after intrathecal injection and effectively scavenged reactive oxygen species (ROS) for inhibiting oxidative stress. The infarct size was reduced, and neurological function was restored in cerebral I/R injury rat models. As a proof-of-concept, the intrathecal injection of nano-antioxidants is an excellent therapeutic strategy to ameliorate cerebral I/R injury.
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