期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 49, 页码 45455-45466出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b16637
关键词
multidrug resistance; targeting therapy; mimic vesicles; drug delivery system; RNAi
资金
- National Natural Science Foundation of China [81801837, 21904135, 21575154, 21775160]
- Science Foundation of Jiangsu Province [BE2018665, BK20180258, BK20180251]
- China Postdoctoral Science Foundation [2018M630620, 2019T120475]
Multidrug resistance (MDR) remains one of the most important challenges to clinical chemotherapeutics. In this study, versatile mimic vesicles (MVs) derived from Aptamer erythrocytes were investigated as delivery systems for siRNA and doxorubicin (DOX) to treat MDR tumors. The carriers could be readily obtained through extruding erythrocyte membranes and had the advantages of biological homogeneity, high output, controllable size, low cost, and excellent biocompatibility. Moreover, aptamers modified on the MVs endowed the carriers with tumor-targeting capacity. DOX and P-glycoprotein (P-gp) siRNA were loaded onto the MVs through incubation and cholesterol-mediated methods, achieving high loading rates and targeted tumor delivery. The drugloaded carriers could successfully overcome drug resistance and synergistically kill MDR tumors through P-gp silencing and DOX-induced growth inhibition. This MV-based drug delivery system therefore provides new insights into the synergistic targeting of MDR tumors and offers an alternative delivery strategy to overcome MDR.
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