期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 50, 页码 47619-47624出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b18160
关键词
breathing proteinosomes; unfolding and refolding; denaturants-response; swelling and shrinkage; on/off switchable fluorescence
资金
- National Key R&D Program of China [2018YFA0901600]
- National Natural Science Foundation of China [21420102007, 21574056]
The design and construction of breathing self-assemblies has been a rather popular topic due to their potential in materials science and nanotechnology. Inspired by the breathing behavior of natural jellyfish, herein, we presented the construction of a giant breathing proteinosome through an interfacial self-assembly of proteins and surfactants at the oil/water interface of emulsions: The proteinosome displays breathing behavior and can swell and shrink for multiple cycles by protein folding and unfolding through the alternate addition and removal of denaturant; more importantly, when green fluorescent proteins were selected as alternative protein building blocks, the fluorescence of proteinosome can be reversibly switched on/off just like the behavior of jellyfish. Moreover, accompanied by reversible swelling and shrinking and on/off fluorescence, the expanded and shrunk membrane pore can be tuned for distinguishing quantum dots of different sizes. The folding-responsive breathing behavior of intelligent proteinosomes provides a platform for functional biomaterials.
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