期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 50, 页码 46558-46571出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b17543
关键词
lotus seedpod; porous; microspheres; ultrarapid; hemostasis
资金
- Wenzhou Science and Technology Major Project [ZS2017023, ZY2019018]
- Wenzhou Science and Technology Public Project [G20180029]
- Wenzhou Institute, University of Chinese Academy of Sciences startup fund [WIUCASQD2019006]
- Zhejiang Province Welfare Technology Applied Research Project [LGF20C100002]
- Scientific Research Fund of National Health Commission [WKJ-ZJ-1707]
- Wenzhou Longwan District (High-tech Zone) Science and Technology Project [2018KG10Z]
- Project of State Key Laboratory of Ophthalmology, Optometry and Visual Science, Wenzhou Medical University [K171204]
- State Key Project of Research and Development [2016YFC1100300]
- National Natural Science Foundation of China [31370969, 51673145]
- International Science & Technology Cooperation Program of China [2013DFG52040]
Rapid water absorption rate has become a bottleneck that limits ultrarapid hemostatic performance of hemostatic micro spheres. Herein, we reported a lotus seedpod surface-like polysaccharide hemostatic microsphere (PHM) with macropits on surface morphology and micropores in macropits structure. Unique macropits on surface can promote the water absorption rate because they are advantageous to quickly guide blood into the micropores. Special micropores are internally connected with each other, which endows PHM4 with high water absorption ratio. During the process of blood entering the micropores from micropits, the pore size decreases gradually. In this way, blood clotting factors could be rapidly concentrated. PHM4 showed the highest water absorption rate (40.7 mL/s/cm(2)) and rapid hemostatic property in vivo (hemostatic time shortened from 210 to 45 s). Lotus seedpod surface-like PHMs are believed to have further clinical application as an effective hemostasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据