期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 48, 页码 45007-45015出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b18891
关键词
tissue photobonding; Rose Bengal; collagen; peptide; wound healing
资金
- Natural Sciences and Engineering Research council (NSERC)
- Canadian Institutes of Health Research (CIHR)
- Ministry of Economic Development, Job Creation and Trade
- NSERC
- Canadian Foundation for Innovation (JELF program)
- Queen's University
- University of Ottawa Cardiac Endowment Fund at the Heart Institute
- FONDECYT [1171155]
- Iniciativa Cientifica Milenio of the Ministry of Economy, Development and Tourism (Chile)
Using chemically modified extracellular matrix proteins, such as collagen, in combination with light for tissue bonding reduces inflammation and minimizes scarring. However, full length animal or recombinant human collagen proteins are difficult to isolate/produce. Thus, short biomimetic collagen peptides with properties equivalent to collagen at both structural and functional levels may be ideal building blocks for the development of remotely triggered adhesives and fillers. In this work, the conjugation of self-assembling collagen-like peptides to acrylate functionalized polyethylene glycol units yielded adhesive filler materials activated by visible light through the incorporation of a photosensitizer. When tested in a murine skin wound model, the photoactivated adhesives showed reduced scar formation and promoted epithelial regeneration.
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