期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 48, 页码 44970-44977出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b17716
关键词
photodynamic therapy; photothermal therapy; photoacoustic imaging; synergetic cancer treatment; DAF nanoparticles
资金
- NNSF of China [61525402, 61775095, 21704043, 81872255]
- Jiangsu Provincial key research and development plan [BE2017741]
- Natural Science Foundation of Jiangsu Province [BK20170990]
- Six talent peak innovation team in Jiangsu Province [TD-SWYY-009]
- Key medical talents fund of Jiangsu Province [2016KJQWZDRC-03]
A synergetic phototheranostic system, combining diagnostic photo-imaging and phototherapies [such as photothermal therapy and photodynamic therapy (PDT)], shows great potential in today's tumor precise therapy. Herein, we fabricate near-infrared (NIR) light-harvesting fullerene-based nanoparticles (DAF NPs) for photoacoustic (PA) imaging-guided synergetic tumor photothermal and PDT. The fullerene derivatives (DAF) absorbing in the NIR region have been synthesized by conjugating NIR-absorbing antenna with fullerene. In addition, DAF NPs with good biocompatibility have been fabricated via a nanoprecipitation approach. The as-prepared DAF NPs can accumulate and generate PA signals around the tumor site 6 h post injection via enhanced permeability and retention effect in vivo. More importantly, the DAF NPs exhibit better reactive oxygen species and heat generation efficacy compared with fullerene and antenna nanoparticles (DA NPs), respectively. Further in vitro and in vivo studies demonstrate that DAF NPs can effectively inhibit tumor growth through synergetic photodynamic and photothermal therapies, which provides a new sight of photosensitizer design for enhanced cancer phototheranostics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据