期刊
ACS APPLIED MATERIALS & INTERFACES
卷 11, 期 45, 页码 42734-42743出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b14286
关键词
microfluidics; polymer particles; interfacial instability; emulsion-solvent evaporation; phase separation; self-assembly; immune activation; dendritic cell
资金
- Natural Science Foundation of China [51525302, 51473059]
- Natural Science Foundation of Hubei Scientific Committee [2016CFA001]
- Program for HUST Academic Frontier Youth Team [2015-01]
- Fundamental Research Funds for the Central Universities [20191dyXJJS077]
In this report, we present a facile approach to produce biodegradable polymeric microparticles with uniform sizes and controllable morphologies by blending hydrophobic poly(D, L-lactic-co-glycolide) (PLGA) and amphiphilic poly(D, L-lactic acid)-b-poly(ethylene glycol) (PLA-b-PEG) in a microfluidic chip. Microparticles with tentacular, hollow hemispherical, and Janus structures were obtained after complete evaporation of the organic solvent by manipulating the interfacial behavior of emulsion droplets and the phase separation behavior inside the droplets. The number and length of the tentacles on the surface of tentacular microparticles could be tailored by varying the initial concentration and blending ratios of the polymers. The organic solvent played an important role in controlling the morphologies of microparticles. For example, blending PLA(16k)-b-PEG(5k) with PLGA(1)(00k) in dichloromethane resulted in tentacular microparticles, whereas hollow hemispherical microparticles were obtained in trichloromethane. Moreover, these microparticles with controllable shapes and surface textures have significant influence on the immune response of dendritic cells (DCs), showing a morphology-dependent enhancement of DC maturation.
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