期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1859, 期 1, 页码 102-111出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2015.05.006
关键词
Long noncoding RNA; Genomic imprinting; Chromatin; Epigenetics; Noncoding RNA; lncRNA
资金
- Knut and Alice Wallenberg Foundation (KAW) [KAW 2014.0057]
- Swedish Foundation for Strategic Research [RB13-0204]
- Swedish Cancer Research foundation [140317]
- Swedish Research Council [VR-M: K2014-67X-20781-07-4]
- Barncancerfonden [PR2014/0147]
- Biocare/GU
- LUA/ALF
Genomic imprinting has been a great resource for studying transcriptional and post-transcriptional-based gene regulation by long noncoding RNAs (lncRNAs). In this article, I overview the functional role of intergenic lncRNAs (H19, IPW, and MEG3), antisense lncRNAs (Kcnq1ot1, Airn, Nespas, Ube3a-ATS), and enhancer lncRNAs (IG-DMR eRNAs) to understand the diverse mechanisms being employed by them in cis and/or trans to regulate the parent-of-origin specific expression of target genes. Recent evidence suggests that some of the IncRNAs regulate imprinting by promoting intra-chromosomal higher-order chromatin compartmentalization, affecting replication timing and subnuclear positioning. Whereas others act via transcriptional occlusion or transcriptional collision-based mechanisms. By establishing genomic imprinting of target genes, the lncRNAs play a critical role in important biological functions, such as placental and embryonic growth, pluripotency maintenance, cell differentiation, and neural-related functions such as synaptic development and plasticity. An emerging consensus from the recent evidence is that the imprinted lncRNAs fine-tune gene expression of the protein-coding genes to maintain their dosage in cell. Hence, lncRNAs from imprinted clusters offer insights into their mode of action, and these mechanisms have been the basis for uncovering the mode of action of lncRNAs in several other biological contexts. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa. (C) 2015 Elsevier B.V. All rights reserved.
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