期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1859, 期 4, 页码 663-674出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2016.02.002
关键词
KRAS; HRAS; NRAS; G-quadruplex; Antigene strategies; Promoter; 5 '-UTR
资金
- AIRC (Italian association for cancer research) [14301]
It is now well established that in the human genome the canonical double helix coexists with folded G-quadruplex structures that are known to have important biological functions. In this review we summarize the current knowledge on quadruplex formation in the promoters of the ras genes that are mutated in about 30% of all human cancers. We describe the nuclear proteins that recognize these unusual DNA structures and discuss their function in transcription. We also examine the formation of G-quadruplexes in the 5'-untranslated region of the ras transcripts and conclude this review by reporting strategies that use either ras G-quadruplexes or proteins recognizing the ras G-quadruplexes as targets of anticancer small molecules. (C) 2016 Elsevier B.V. All rights reserved.
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