期刊
BIOMOLECULES
卷 9, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/biom9090406
关键词
major depressive disorder; bipolar disorder; creatine; phosphocreatine
资金
- U.S. Department of Veterans Affairs (VA) Rocky Mountain VISN 19 Mental Illness Research, Education and Clinical Center (MIRECC)
- VA grant [I01-CX000812, I01-CX001611]
- National Alliance for Research on Schizophrenia and Depression Young Investigator Grant (2016)
Depressed mood, which can occur in the context of major depressive disorder, bipolar disorder, and other conditions, represents a serious threat to public health and wellness. Conventional treatments are not effective for a significant proportion of patients and interventions that are often beneficial for treatment-refractory depression are not widely available. There is, therefore, an immense need to identify novel antidepressant strategies, particularly strategies that target physiological pathways that are distinct from those addressed by conventional treatments. There is growing evidence from human neuroimaging, genetics, epidemiology, and animal studies that disruptions in brain energy production, storage, and utilization are implicated in the development and maintenance of depression. Creatine, a widely available nutritional supplement, has the potential to improve these disruptions in some patients, and early clinical trials indicate that it may have efficacy as an antidepressant agent.
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