期刊
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
卷 68, 期 2, 页码 45-50出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.retram.2019.08.001
关键词
Histone deacetylases; Insulin resistance; Acetylation; Transcription; beta-cell destruction; Gene expression
Objective: The role of histone deacetylases has come out as an emerging remedy in control and treatment of various metabolic disorders and cancers. This review highlights their intricate role in diabetes mellitus as well as its associated complications. Key findings: Through recent studies and reports the role of various epigenetic markers in treatment of diabetes mellitus has been revealed. HDAC enzyme regulates the structure of chromatin and transcripts genes in the nucleus synthesizing various proteins that control metabolic activities in the body. It mainly acts by removing an acetyl group from its precursor protein thereby modulating gene expression and regulates the metabolic enzyme acetylation in mitochondria and cytosol. Summary: The present review focus on the intrinsic role of HDAC inhibitors as an emerging remedy for diabetes and its complications demonstrating their use in preventing resistance of beta-cells towards insulin, destruction of beta-cells and provide protection against cytokine mediated attack on pancreatic cells. (C) 2019 Elsevier Masson SAS. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据