4.5 Review

Pore-forming toxins: Properties, diversity, and uses as tools to image sphingomyelin and ceramide phosphoethanolamine

期刊

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1858, 期 3, 页码 576-592

出版社

ELSEVIER
DOI: 10.1016/j.bbamem.2015.10.012

关键词

Lipid domains; Lipid imaging; Actinoporin; Aegerolysin; Lysenin; Equinatoxin

资金

  1. Lipid Dynamics Program
  2. Cell System Program
  3. Integrated Lipidology Program of RIKEN
  4. Ministry of Education, Culture, Sports, Science and Technology of Japan [23659047, 23460081, 22390018, 25293015]
  5. Naito Foundation
  6. Grants-in-Aid for Scientific Research [25293015, 23659047] Funding Source: KAKEN

向作者/读者索取更多资源

Pore-forming toxins (PFTs) represent a unique class of highly specific lipid-binding proteins. The cytotoxicity of these compounds has been overcome through crystallographic structure and mutation studies, facilitating the development of non-toxic lipid probes. As a consequence, non-toxic PFTs have been utilized as highly specific probes to visualize the diversity and dynamics of lipid nanostructures in living and fixed cells. This review is focused on the application of PFTs and their non-toxic analogs as tools to visualize sphingomyelin and ceramide phosphoethanolamine, two major phosphosphingolipids in mammalian and insect cells, respectively. This article is part of a Special Issue entitled: Pore-Forming Toxins edited by Mauro Dalla Serra and Franco Gambale. (C) 2015 Elsevier B.V. All rights reserved.

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