期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1858, 期 3, 页码 576-592出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2015.10.012
关键词
Lipid domains; Lipid imaging; Actinoporin; Aegerolysin; Lysenin; Equinatoxin
资金
- Lipid Dynamics Program
- Cell System Program
- Integrated Lipidology Program of RIKEN
- Ministry of Education, Culture, Sports, Science and Technology of Japan [23659047, 23460081, 22390018, 25293015]
- Naito Foundation
- Grants-in-Aid for Scientific Research [25293015, 23659047] Funding Source: KAKEN
Pore-forming toxins (PFTs) represent a unique class of highly specific lipid-binding proteins. The cytotoxicity of these compounds has been overcome through crystallographic structure and mutation studies, facilitating the development of non-toxic lipid probes. As a consequence, non-toxic PFTs have been utilized as highly specific probes to visualize the diversity and dynamics of lipid nanostructures in living and fixed cells. This review is focused on the application of PFTs and their non-toxic analogs as tools to visualize sphingomyelin and ceramide phosphoethanolamine, two major phosphosphingolipids in mammalian and insect cells, respectively. This article is part of a Special Issue entitled: Pore-Forming Toxins edited by Mauro Dalla Serra and Franco Gambale. (C) 2015 Elsevier B.V. All rights reserved.
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