期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1858, 期 10, 页码 2431-2440出版社
ELSEVIER
DOI: 10.1016/j.bbamem.2016.02.030
关键词
Molecular dynamics; Pulmonary surfactant; Lipid monolayer; Monolayer collapse; Surfactant protein; Surfactant reservoir
资金
- Natural Sciences and Engineering Research Council (Canada) [RGPIN-238357]
- Natural Sciences and Engineering Research Council (Canada) [RGPIN-238357]
Lung surfactant lines the gas-exchange interface in the lungs and reduces the surface tension, which is necessary for breathing. Lung surfactant consists mainly of lipids with a small amount of proteins and forms a monolayer at the air-water interface connected to bilayer reservoirs. Lung surfactant function involves transfer of material between the monolayer and bilayers during the breathing cycle. Lipids and proteins are organized laterally in the monolayer; selected species are possibly preferentially transferred to bilayers. The complex 3D structure of lung surfactant and the exact roles of lipid organization and proteins remain important goals for research. We review recent simulation studies on the properties of lipid monolayers, monolayers with phase coexistence, monolayer-bilayer transformations, lipid-protein interactions, and effects of nanoparticles on lung surfactant. This article is part of a Special Issue entitled: Biosimulations edited by Ilpo Vattulainen and Tomasz Rog. (C) 2016 Elsevier B.V. All rights reserved.
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