期刊
PHARMACEUTICS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics11090448
关键词
AMPs; HDPs; carriers; delivery; antimicrobial agents
资金
- MINECO [CTQ2017-86224-P]
- Consortium IMMUNOTHERCAN-CM [B2017/BMD-3733]
- NANODENDMED II-CM [B2017/BMD-3703]
- VI National R&D&i Plan 2008-2011
- Iniciativa Ingenio 2010
- Consolider Program
- CIBER Actions
- Instituto de Salud Carlos III
- European Regional Development Fund
- [SBPLY/17/180501/000358 JCCM]
- [CCGP2017-EXp/023]
Recently, antimicrobial peptides (AMPs), also called host defence peptides (HDPs), are attracting great interest, as they are a highly viable alternative in the search of new approaches to the resistance presented by bacteria against antibiotics in infectious diseases. However, due to their nature, they present a series of disadvantages such as low bioavailability, easy degradability by proteases, or low solubility, among others, which limits their use as antimicrobial agents. For all these reasons, the use of vehicles for the delivery of AMPs, such as polymers, nanoparticles, micelles, carbon nanotubes, dendrimers, and other types of systems, allows the use of AMPs as a real alternative to treatment with antibiotics.
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