期刊
FRONTIERS IN ONCOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2019.00920
关键词
long non-coding RNA; microRNA; biomarker; therapeutics; cancer
类别
资金
- National Natural Science Foundation of China [81972789]
- National Science and Technology Major Project [2018ZX10302205-004-002]
- Natural Science Foundation of Jiangsu Province [BK20161130]
- Six Talent Peaks Project in Jiangsu Province [SWYY-128]
- Technology Development Funding of Wuxi [WX18IVJN017]
- Major Project of Science and Technology in Henan Province [161100311400]
- Research Funds for the Medical School of Jiangnan University ESI Special Cultivation Project [1286010241170320]
Alterations and personal variations of RNA interactions have been mechanistically coupled with disease etiology and phenotypical variations. RNA biomarkers, RNA mimics, and RNA antagonists have been developed for diagnostic, prognostic, and therapeutic uses. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are two major types of RNA molecules with regulatory roles, deregulation of which has been implicated in the initiation and progression of many human malignancies. Accumulating evidence indicated the clinical roles of regulatory RNAs in cancer control, stimulating a surge in exploring the functionalities of regulatory RNAs for improved understanding on disease pathogenesis and management. In this review, we highlight the critical roles of lncRNAs and miRNAs played in tumorigenesis, scrutinize their potential functionalities as diagnostic/prognostic biomarkers and/or therapeutic targets in clinics, outline opportunities that ncRNAs may bring to complement current clinical practice for improved cancer management and identify challenges faced by translating frontier knowledge on non-coding RNAs (ncRNAs) to bedside clinics as well as possible solutions.
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