期刊
CELLS
卷 8, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/cells8090989
关键词
CTC; heterogeneity; liquid biopsy; liquid surgery; clinical utility
类别
资金
- intramural 5x1000, IOV-Sinergia tra Oncologia e Clinica (NSCLC MUT)
- FP7-HEALTH-2012-INNOVATION (CTC-TRAP:EUFP7 grant) [305341]
- intramural 5x1000, IOV-Sinergia tra Oncologia e Clinica (MET)
- Programma Operativo FESR Regione Emilia-Romagna 2014/2020 [PG/2018/630591]
Circulating tumor cells (CTCs) are cellular elements that can be scattered into the bloodstream from primary cancer, metastasis, and even from a disseminated tumor cell (DTC) reservoir. CTCs are seeds, able to give rise to new metastatic lesions. Since metastases are the cause of about 90% of cancer-related deaths, the significance of CTCs is unquestionable. However, two major issues have stalled their full clinical exploitation: rarity and heterogeneity. Therefore, their full clinical potential has only been predicted. Finding new ways of studying and using such tremendously rare and important events can open new areas of research in the field of cancer research, and could drastically improve tumor companion diagnostics, personalized treatment strategies, overall patients management, and reduce healthcare costs.
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