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The importance of estimating the therapeutic index in the development of matrix metalloproteinase inhibitors
JT Peterson
CARDIOVASCULAR RESEARCH (2006)
Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates
G Pochetti et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice
Bettina Hartenstein et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2006)
Matrix metalloproteinases: roles in cancer and metastasis
B Fingleton
FRONTIERS IN BIOSCIENCE-LANDMARK (2006)
Design, modelling, synthesis and biological evaluation of peptidomimetic phosphinates as inhibitors of matrix metalloproteinases MMP-2 and MMP-8
G Bianchini et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2005)
Matrix metalloproteinases as therapeutic targets in cancer
P Vihinen et al.
CURRENT CANCER DRUG TARGETS (2005)
Future challenges facing the development of specific active-site-directed synthetic inhibitors of MMPs
P Cuniasse et al.
BIOCHIMIE (2005)
Distinct roles for the catalytic and hemopexin domains of membrane type 1-matrix metalloproteinase in substrate degradation and cell migration
J Cao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Subantimicrobial dose doxycycline enhances the efficacy of scaling and root planning chronic periodontitis: A multicenter trial
PM Preshaw et al.
JOURNAL OF PERIODONTOLOGY (2004)
Matrix metalloproteinases as modulators of inflammation and innate immunity
WC Parks et al.
NATURE REVIEWS IMMUNOLOGY (2004)
Activity-based probes for the proteomic profiling of metalloproteases
A Saghatelian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix
TH Chun et al.
JOURNAL OF CELL BIOLOGY (2004)
Carbamoylphosphonates, a new class of in vivo active matrix metalloproteinase inhibitors.: 1.: Alkyl- and cycloalkylcarbamoylphosphonic acids
E Breuer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin A after intraperitoneal administration to mice
L Sanderson et al.
DRUG METABOLISM AND DISPOSITION (2004)
A bioinorganic perspective on matrix metalloproteinase inhibition
DT Puerta et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2004)
Minocycline reduces gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis
LM Metz et al.
ANNALS OF NEUROLOGY (2004)
Unveiling the surface Epitopes that render tissue inhibitor of metalloproteinase-1 inactive against membrane type 1-matrix metalloproteinase
MH Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator
XY Wang et al.
NATURE MEDICINE (2003)
Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3
LA Reiter et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Diastereoselective solution and multipin-based combinatorial array synthesis of a novel class of potent phosphinic metalloprotease inhibitors
A Makaritis et al.
CHEMISTRY-A EUROPEAN JOURNAL (2003)
Protein engineering of the tissue inhibitor of metalloproteinase 1 (TIMP-1) inhibitory domain - In search of selective matrix metalloproteinase inhibitors
S Wei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Strategies for MMP inhibition in cancer:: Innovations for the post-trial era
CM Overall et al.
NATURE REVIEWS CANCER (2002)
Matrix metalloproteinases and their role in pancreatic cancer: A review of preclinical studies and clinical trials
M Bloomston et al.
ANNALS OF SURGICAL ONCOLOGY (2002)
A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
SR Bramhall et al.
BRITISH JOURNAL OF CANCER (2002)
Matrix metalloproteinase inhibitors: Do they have a place in anticancer therapy?
MA Rudek et al.
PHARMACOTHERAPY (2002)
MT1-MMP, but not secreted MMPs, influences the migration of human microvascular endothelial cells in 3-dimensional collagen gels
T Koike et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2002)
Metalloproteases and inhibitors in arthritic diseases
J Martel-Pelletier et al.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2001)
Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling
BG Gálvez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Phosphinic peptide inhibitors of macrophage metalloelastase (MMP-12). Selectivity and mechanism of binding
CB Schiodt et al.
CURRENT MEDICINAL CHEMISTRY (2001)
Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome
JA Martignetti et al.
NATURE GENETICS (2001)
Crystal structure of the Stromelysin-3 (MMP-11) catalytic domain complexed with a phosphinic inhibitor mimicking the transition-state
AL Gall et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
Solid phase combinatorial library of phosphinic peptides for discovery of matrix metalloproteinase inhibitors
J Buchardt et al.
JOURNAL OF COMBINATORIAL CHEMISTRY (2000)
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
G Bergers et al.
NATURE CELL BIOLOGY (2000)
Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: Implications for drug design
E Gavuzzo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I
ZJ Zhou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
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