期刊
CANCERS
卷 11, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/cancers11081195
关键词
heat shock protein 27; HSP27 inhibitor; anti-cancer drugs; resistance
类别
资金
- National Research Foundation of Korea [NRF-2017R1A2B2002327, NRF-2017M2A2A702019560, 2018R1A5A2025286]
- Korean government (Ministry of Science and ICT)
Heat shock protein 27 (HSP27), induced by heat shock, environmental, and pathophysiological stressors, is a multi-functional protein that acts as a protein chaperone and an antioxidant. HSP27 plays a significant role in the inhibition of apoptosis and actin cytoskeletal remodeling. HSP27 is upregulated in many cancers and is associated with a poor prognosis, as well as treatment resistance, whereby cells are protected from therapeutic agents that normally induce apoptosis. This review highlights the most recent findings and role of HSP27 in cancer, as well as the strategies for using HSP27 inhibitors for therapeutic purposes.
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