期刊
JOURNAL OF CLINICAL MEDICINE
卷 8, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/jcm8081161
关键词
acute respiratory distress syndrome; positive end-expiratory pressure; electrical impedance tomography; computed tomography; monitoring; functional imaging
资金
- German Research Council (Deutsche Forschungsgemeinschaft, DFG) [PU 219/2-1, WR47-1-1]
- Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Germany
Avoiding tidal recruitment and collapse during mechanical ventilation should reduce the risk of lung injury. Electrical impedance tomography (EIT) enables detection of tidal recruitment by measuring regional ventilation delay inhomogeneity (RVDI) during a slow inflation breath with a tidal volume (V-T) of 12 mL/kg body weight (BW). Clinical applicability might be limited by such high V(T)s resulting in high end-inspiratory pressures (P-EI) during positive end-expiratory pressure (PEEP) titration. We hypothesized that RVDI can be obtained with acceptable accuracy from reduced slow inflation V(T)s. In seven ventilated pigs with experimental lung injury, tidal recruitment was quantified by computed tomography at PEEP levels changed stepwise between 0 and 25 cmH(2)O. RVDI was measured by EIT during slow inflation V(T)s of 12, 9, 7.5, and 6 mL/kg BW. Linear correlation of tidal recruitment and RVDI was excellent for V(T)s of 12 (R-2 = 0.83, p < 0.001) and 9 mL/kg BW (R-2 = 0.83, p < 0.001) but decreased for V(T)s of 7.5 (R-2 = 0.76, p < 0.001) and 6 mL/kg BW (R-2 = 0.71, p < 0.001). With any reduction in slow inflation V-T, P-EI decreased at all PEEP levels. Receiver-Operator-Characteristic curve analyses revealed that RVDI-thresholds to predict distinct amounts of tidal recruitment differ when obtained from different slow inflation V(T)s. In conclusion, tidal recruitment can sufficiently be monitored by EIT-based RVDI-calculation with a slow inflation of 9 mL/kg BW.
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