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New Era of Endoscopic Ultrasound-Guided Tissue Acquisition: Next-Generation Sequencing by Endoscopic Ultrasound-Guided Sampling for Pancreatic Cancer

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JOURNAL OF CLINICAL MEDICINE
卷 8, 期 8, 页码 -

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MDPI
DOI: 10.3390/jcm8081173

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next-generation sequencing; genome sequencing; endoscopic ultrasound-guided tissue acquisition; endoscopic ultrasound-guided fine needle aspiration; endoscopic ultrasound-guided fine needle biopsy; pancreatic cancer; biomarker; precision medicine

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Pancreatic cancer is a lethal cancer with an increasing incidence. Despite improvements in chemotherapy, patients with pancreatic cancer continue to face poor prognoses. Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is the primary method for obtaining tissue samples of pancreatic cancer. Due to advancements in next-generation sequencing (NGS) technologies, multiple parallel sequencing can be applied to EUS-TA samples. Genomic biomarkers for therapeutic stratification in pancreatic cancer are still lacking, however, NGS can unveil potential predictive genomic biomarkers of treatment response. Thus, the importance of NGS using EUS-TA samples is becoming recognized. In this review, we discuss the recent advances in EUS-TA application for NGS of pancreatic cancer.

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