4.8 Review

Advances in the science and treatment of alcohol use disorder

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Summary: Previous studies have suggested that baclofen may be an effective pharmacological approach to treating addictive disorders by disrupting the link between initial drink (priming) and subsequent alcohol consumption (self-administration). However, there is considerable pharmacokinetic variability that needs to be considered when using baclofen as a treatment for alcohol use disorder.

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Nicotine-Use/Smoking Is Associated with the Efficacy of Naltrexone in the Treatment of Alcohol Dependence

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Overcoming the Valley of Death in Medications Development for Alcohol Use Disorder

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Noradrenergic targets for the treatment of alcohol use disorder

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Diagnosis and Pharmacotherapy of Alcohol Use Disorder A Review

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Guidelines for biological treatment of substance use and related disorders, part 1: Alcoholism, first revision

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Mindfulness-Based Interventions for Addictive Behaviors: Implementation Issues on the Road Ahead

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A contextual model of self-regulation change mechanisms among individuals with addictive disorders

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The Microbiota, the Gut and the Brain in Eating and Alcohol Use Disorders: A 'M,nage A Trois'?

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Dysregulation of brain stress systems mediates compulsive alcohol drinking

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Alcohol Use Disorders in Primary Health Care: What Do We Know and Where Do We Go?

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Treatment Seeking for Alcohol Use Disorders: Treatment Gap or Adequate Self-Selection?

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A meta-analysis of brief alcohol interventions for adolescents and young adults: variability in effects across alcohol measures

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Varenicline for Treatment of Alcohol Dependence: A Randomized, Placebo-Controlled Trial

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Heterogeneity of Alcohol Use Disorder: Understanding Mechanisms to Advance Personalized Treatment

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2010 National and State Costs of Excessive Alcohol Consumption

Jeffrey J. Sacks et al.

AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2015)

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Identification and Management of Alcohol Withdrawal Syndrome

Antonio Mirijello et al.

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Topiramate Treatment for Heavy Drinkers: Moderation by a GRIK1 Polymorphism

Henry R. Kranzler et al.

AMERICAN JOURNAL OF PSYCHIATRY (2014)

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Pharmacotherapy for Adults With Alcohol Use Disorders in Outpatient Settings A Systematic Review and Meta-analysis

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)

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Alcohol Use Trajectories Among Non-Treatment-Seeking Heavy Drinkers

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Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis

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Gabapentin Treatment for Alcohol Dependence A Randomized Clinical Trial

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Psychosocial Approaches to Alcohol Use Disorders Since 1940: A Review

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The Placebo Effect in Clinical Trials for Alcohol Dependence: An Exploratory Analysis of 51 Naltrexone and Acamprosate Studies

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ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2013)

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Naltrexone and Nalmefene: Any Meaningful Difference?

Robert M. Swift

BIOLOGICAL PSYCHIATRY (2013)

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Economic Costs of Excessive Alcohol Consumption in the US, 2006

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AMERICAN JOURNAL OF PREVENTIVE MEDICINE (2011)

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Effectiveness and Safety of Baclofen in the Treatment of Alcohol Dependent Patients

Lorenzo Leggio et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2010)

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Placebo-Controlled Trial of Zonisamide for the Treatment of Alcohol Dependence

Albert J. Arias et al.

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Drug harms in the UK: a multicriteria decision analysis

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LANCET (2010)

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Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin

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ADDICTION BIOLOGY (2009)

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Effect of Extended-Release Naltrexone (XR-NTX) on Quality of Life in Alcohol-Dependent Patients

Helen M. Pettinati et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2009)

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Targeted Naltrexone for Problem Drinkers

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JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2009)

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Distinctions Without a Difference: Direct Comparisons of Psychotherapies for Alcohol Use Disorders

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Topiramate for treating alcohol dependence - A randomized controlled trial

Bankole A. Johnson et al.

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Article Medicine, General & Internal

Combined pharmacotherapies and behavioral interventions for alcohol dependence - The COMBINE study: A randomized controlled trial

RF Anton et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)

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Naltrexone depot for treatment of alcohol dependence: A multicenter, randomized, placebo-controlled clinical trial

HR Kranzler et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2004)

Review Psychology, Multidisciplinary

Relapse prevention for alcohol and drug problems - That was Zen, this is Tao

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AMERICAN PSYCHOLOGIST (2004)

Review Substance Abuse

Alcoholism: Allostasis and beyond

GF Koob

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH (2003)

Review Psychology, Clinical

Harm reduction approaches to alcohol use: Health promotion, prevention, and treatment

GA Marlatt et al.

ADDICTIVE BEHAVIORS (2002)

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Using transtheoretical model profiles to differentiate levels of alcohol abstinence success

JP Carbonari et al.

JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY (2000)