Two-Step Preparation of Diverse 3-Amidofurans from Chitin

The synthesis of 3-amidofurans is laborious due to the difficulty installing a nitrogen substituent at the C3 position of the furan heterocycle. 3-Acetamido-5-acetylfuran (3A5AF), readily available from chitin, is a versatile biorenewable platform that can be converted into a range of functionally rich 3-amidofurans, streamlining access to this underexplored heteroaromatic chemical space.