期刊
CHEMISTRYSELECT
卷 4, 期 31, 页码 9247-9251出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201900935
关键词
Antimicrobial activity; Antioxidant activity; MgO nanocatalyst; Multicomponent reaction; Spiro compounds; Spiro[indoline-3; 4 '-[1; 3]dithiine]
资金
- Islamic Azad University (Kerman Branch)
Multi-component reaction indoline-2,3-dione derivatives, malononitrile, carbon disulfide and dimedone have led to newly synthesized 6 '-amino-2 '-(4,4-dimethyl-2,6-dioxocyclohexylidene)-2-oxospiro[indoline-3,4 '-[1,3]dithiine]-5 '-carbonitrile derivatives under acidic and base conditions with high efficiency during a simplified process. In acidic conditions, using MgO nanoparticleas as a catalyst, greater yields in shorter time was observed. The biological effects of synthetic derivatives such as antibacterial and antifungal effects based on inhibition zone diameter, minimum inhibitory concentration, minimum bactericidal concentration, minimum fungicidal concentration and antioxidant effects on DPPH free radical, have been the subject of previous studies. The results showed that some derivatives show higher antimicrobial effects compared to commercial drugs.
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