期刊
FRONTIERS IN PSYCHIATRY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2019.00603
关键词
naltrexone; resting-state functional magnetic resonance imaging; methamphetamine; striatum; functional connectivity
类别
资金
- U.S. National Institutes of Health, National Institute on Drug Abuse [R21DA033182, P50DA018165 07, UG1DA015815, T32DA007262, T32AA007468]
- National Center for Research Resources (NCRR) of the National Institutes of Health (NIH)
- NIH Roadmap for Medical Research [1 UL1 RR024140 01]
- Department of Veterans Affairs Clinical Sciences Research and Development Merit Review Program [I0CX001558, IK2CX001790]
- Oregon Health and Science University Collins Medical Trust [APSYC0249]
- Medical Research Foundation of Oregon [APSYC0250]
Naltrexone attenuates craving, and the subjective effects of methamphetamine and extended-release naltrexone (XR-NTX) reduces functional connectivity between regions of the striatum and limbic cortex. Naltrexone modulates neural activity at dopaminergic synapses; however, it is unclear whether naltrexone has an effect on large-scale brain networks. Functional networks interact to coordinate behavior, and as substance-use disorders are associated with an imbalance between reward and cognitive control networks, treatment approaches that target interactive brain systems underlying addiction may be a useful adjunct for behavioral therapies. The objective of this study was to examine the effect of XR-NTX on large-scale brain networks and to determine whether changes in network relationships attenuate drug use, craving, and addiction severity. Thirty-nine participants in or seeking treatment for methamphetamine-use disorder were enrolled in a clinical trial of XR-NTX between May 2013 and March 2015 (Clinicaltrials. gov NCT01822132). Functional magnetic resonance imaging (fMRI) and questionnaires were conducted before and after double-blinded randomization to a 4-week injection of XR-NTX or placebo. In the XR-NTX group, methamphetamine use was reduced along with a decrease in the coupling between executive control (ECN) and default mode (DMN) networks. As decoupling of ECN and DMN networks was associated with change in the severity of dependence, the results suggest that XR-NTX may modulate and enhance ECN attentional resources and suppress DMN self-referential and emotional processing. This study identifies the effect of naltrexone on changes in the intrinsic functional coupling of large-scale brain networks and provides a more systematic understanding of how large-scale networks interact to promote behavioral change in methamphetamine-use disorder.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据