4.6 Article

Association of Transfusion With Risks of Dementia or Alzheimer's Disease: A Population-Based Cohort Study

期刊

FRONTIERS IN PSYCHIATRY
卷 10, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2019.00571

关键词

transfusion; dementia; Alzheimer's disease; cohort study; Taiwan National Health Insurance Research Database

资金

  1. Ministry of Health and Welfare, Taiwan [MOHW108-TDU-B-212-133004]
  2. China Medical University Hospital [DMR-107-192]
  3. Academia Sinica Stroke Biosignature Project [BM10701010021]
  4. MOST Clinical Trial Consortium for Stroke [MOST 107-2321-B-039 -004-]
  5. Tseng-Lien Lin Foundation, Taichung, Taiwan
  6. Katsuzo and Kiyo Aoshima Memorial Funds, Japan

向作者/读者索取更多资源

Purpose: The association between neurodegenerative diseases and transfusion remains to be investigated. Methods: The study population comprised 63,813 patients who underwent a blood transfusion and 63,813 propensity score-matched controls between 2000 and 2010. Data were obtained from the Taiwan National Health Insurance Research Database, which is maintained by the National Health Research Institutes. A Cox regression analysis was conducted to elucidate the relationship between blood transfusions and the risk of dementia. Results: A multivariate Cox regression analysis of factors, such as age, sex, cardiovascular ischemia disease, and depression, revealed that patients who underwent a blood transfusion showed a 1.73-fold higher risk of dementia [95% confidence interval (CI) = 1.62-1.84] and a 1.37-fold higher risk of Alzheimer's disease (AD) [95% CI = 1.13-1.66] than those who did not. Patients who received a transfusion of washed red blood cells showed a 2.37-fold higher risk of dementia (95% CI = 1.63-3.44) than those who did not. Conclusion: Blood transfusion, especially transfusion of any type of red blood cells is associated with an increased risk of dementia.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据