期刊
BIOCHEMISTRY-MOSCOW
卷 81, 期 10, 页码 1038-1043出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0006297916100023
关键词
mitochondria; translation; mRNA localization; ribosome; RNA binding proteins
资金
- Israel Science Foundation [1096/13]
- Binational Science Foundation [2011013]
- Nevet program of the Russell Berrie Nanotechnology Institute
- Lorry Lokey Interdisciplinary Center
- Russell Berrie Nanotechnology Institute
The diverse functions of mitochondria depend on hundreds of different proteins. The vast majority of these proteins is encoded in the nucleus, translated in the cytosol, and must be imported into the organelle. Import was shown to occur after complete synthesis of the protein, with the assistance of cytosolic chaperones that maintain it in an unfolded state and target it to the mitochondrial translocase of the outer membrane (TOM complex). Recent studies, however, identified many mRNAs encoding mitochondrial proteins near the outer membrane of mitochondria. Translation studies suggest that many of these mRNAs are translated locally, presumably allowing cotranslational import into mitochondria. Herein we review these data and discuss its relevance for local protein synthesis. We also suggest alternative roles for mRNA localization to mitochondria. Finally, we suggest future research directions, including revealing the significance of localization to mitochondria physiology and the molecular players that regulate it.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据