期刊
REDOX BIOLOGY
卷 26, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.redox.2019.101255
关键词
Immunometabolism; Mitochondrial function; Cell fate; And immune cells
资金
- Sao Paulo Research Foundation (FAPESP) [2014/10910-7, 2015/15626-8, 2015/26682-6, 2016/18031-8, 2017/05264-7]
- National Council for Scientific and Technological Development (CNPq)
- FAEPEX
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [15/15626-8, 15/26682-6] Funding Source: FAPESP
Nearly 130 years after the first insights into the existence of mitochondria, new rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell fate, mitochondria integrate cell physiology, signaling pathways and metabolism. Thus, recent research has focused on understanding how these multifaceted functions can be used to improve inflammatory responses and prevent cellular dysfunction. Here, we describe the role of mitochondria on the development and function of immune cells, highlighting metabolic aspects and pointing out some metabolic- independent features of mitochondria that sustain cell function.
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