期刊
MOLECULAR METABOLISM
卷 27, 期 -, 页码 S114-S121出版社
ELSEVIER
DOI: 10.1016/j.molmet.2019.06.025
关键词
Mucosal associated invariant T cells; Metabolic disease; Liver; Pancreas; Diabetes; Microbiota
资金
- Institut la Conference Hippocrate - Servier Group
Background: Metabolic diseases represent a wide category of alterations affecting metabolism. These pathologies are notably marked by inflammation that implicates the immune system. Mucosal Associated Invariant (MAI)T cells are immune cells expressing a semi-invariant TCR able to recognize bacterial and fungal vitamin B metabolites. MAIT cells can promote inflammation and are present in many organs central to metabolism, suggesting a role in the etiopathology of these diseases. Scope of the review: Here, we will review what is known of the involvement of MAIT cells in metabolic pathologies in humans and mice. Major conclusions: MAIT cells are severely affected, overactivated with a frequency reduction and a phenotype shift from protective to deleterious. Therefore, they might be a novel target to treat, in particular, pancreas and liver metabolic diseases. (C) 2019 Published by Elsevier GmbH.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据