期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
卷 8, 期 2, 页码 664-+出版社
ELSEVIER
DOI: 10.1016/j.jaip.2019.09.014
关键词
Dry skin; Xerosis; Skin barrier; Atopic dermatitis; Eczema; Allergic diseases; Atopy; TEWL; PreventADALL
资金
- Regional Health Board South East
- Norwegian Research Council
- Oslo University Hospital
- University of Oslo
- Health and Rehabilitation Norway
- Foundation for Healthcare and Allergy Research in Sweden-Vardalstiftelsen
- Swedish Asthma and Allergy Association's Research Foundation
- Swedish Research Council-the Initiative for Clinical Therapy Research
- Swedish Heart-Lung Foundation
- SFO-V Karolinska Institutet
- Freemason Child House Foundation in Stockholm
- Ostfold Hospital Trust
- European Union (MeDALL project)
- Norwegian Association of Asthma and Allergy
- Kloster foundation
- Thermo Fisher
- Norwegian Society of Dermatology and Venereology
- Arne Ingel's bequest
BACKGROUND: Dry skin is associated with increased transepidermal water loss (TEWL), which has been found to precede atopic dermatitis (AD) in childhood. OBJECTIVE: We aimed to identify parental, prenatal, and perinatal predictive factors of dry skin, high TEWL, and AD at 3 months of age, and to determine if dry skin or high TEWL at 3 months can predict AD at 6 months. METHODS: From the Preventing Atopic Dermatitis and Allergies in children prospective birth cohort study, we included 1150 mother-child pairs. Dry skin, TEWL, and eczema were assessed at 3- and 6-month investigations. Eczema, used as a proxy for AD, was defined as the presence of eczematous lesions, excluding differential diagnoses to AD. High TEWL was defined as TEWL >90th percentile, equaling 11.3 g/m(2)/h. Potential predictive factors were recorded from electronic questionnaires at 18- and 34-week pregnancy and obstetric charts. RESULTS: Significant predictive factors (P < .05) for dry skin at 3 months were delivery >38 gestational weeks and paternal age >37 years; for high TEWL, male sex, birth during winter season, and maternal allergic disease; and for eczema, elective caesarean section, multiparity, and maternal allergic diseases. Dry skin without eczema at 3 months was predictive for eczema at 6 months (adjusted odds ratio: 1.92, 95% confidence interval: 1.21-3.05; P = .005), whereas high TEWL at 3 months was not. CONCLUSION: In early infancy, distinct parental- and pregnancy-related factors were predictive for dry skin, high TEWL, and AD. Dry skin at 3 months of age was predictive for AD 3 months later. (C) 2019 American Academy of Allergy, Asthma & Immunology
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