期刊
FRONTIERS IN IMMUNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.02278
关键词
NK cell; metabolism; glucose; glycolysis; amino acid; hypoxia; tumor microenvironment; TME
类别
资金
- Health Department, Basque Government [2018222038]
- Basque Foundation for Research and Innovation-EiTB Maratoia [BIO14/TP/003]
- AECC-Spanish Association Against Cancer [PROYE16074BORR]
- Jesus de Gangoiti Barrera Foundation [FJGB18/002]
- Department of Education, Basque Government [PRE_2018_1_0032, PRE_2018_ 2_0211]
- Instituto de Salud Carlos III-Contratos Sara Borrell [CD17/00128]
- European Social Fund (ESF)-The ESF invests in your future
Natural Killer (NK) cells are characterized by their potential to kill tumor cells by different means without previous sensitization and have, therefore, become a valuable tool in cancer immunotherapy. However, their efficacy against solid tumors is still poor and further studies are required to improve it. One of the major restrictions for NK cell activity is the immunosuppressive tumor microenvironment (TME). There, tumor and other immune cells create the appropriate conditions for tumor proliferation while, among others, preventing NK cell activation. Furthermore, NK cell metabolism is impaired in the TME, presumably due to nutrient and oxygen deprivation, and the higher concentration of tumor-derived metabolic end products, such as lactate. This metabolic restriction of NK cells limits their effector functions, and it could represent a potential target to focus on to improve the efficacy of NK cell-based therapies against solid tumors. In this review, we discuss the potential effect of TME into NK cell metabolism and its influence in NK cell effector functions.
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