相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。A lipase-independent pathway of lipid release and immune modulation by adipocytes
Stephen E. Flaherty et al.
SCIENCE (2019)
Exosomes: biogenesis, biologic function and clinical potential
Yuan Zhang et al.
CELL AND BIOSCIENCE (2019)
Immunometabolism at the interface between macrophages and pathogens
David G. Russell et al.
NATURE REVIEWS IMMUNOLOGY (2019)
Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism
Graeme I. Lancaster et al.
CELL METABOLISM (2018)
Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF-κB/MAPK/PI3K Signaling Systems
Shihab Kochumon et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2018)
Cross-talk between insulin signalling and LPS responses in mouse macrophages
Soumojit Pal et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2018)
Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue
David A. Hill et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection
Sue Tsai et al.
CELL METABOLISM (2018)
Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release
Sho Morioka et al.
NATURE (2018)
Downregulation of macrophage Irs2 by hyperinsulinemia impairs IL-4-indeuced M2a-subtype macrophage activation in obesity
Tetsuya Kubota et al.
NATURE COMMUNICATIONS (2018)
Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation
Marta Riera-Borrull et al.
JOURNAL OF IMMUNOLOGY (2017)
Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization
Eleni Vergadi et al.
JOURNAL OF IMMUNOLOGY (2017)
High glucose induces alternative activation of macrophages via PI3K/Akt signaling pathway
Jie Wang et al.
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2017)
PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity
Ludovic Breasson et al.
SCIENCE SIGNALING (2017)
Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity
Brittney R. Coats et al.
CELL REPORTS (2017)
PI3Kγ activity in leukocytes promotes adipose tissue inflammation and early-onset insulin resistance during obesity
Ludovic Breasson et al.
SCIENCE SIGNALING (2017)
The PI3K Pathway in Human Disease
David A. Fruman et al.
CELL (2017)
Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation
Erez Dror et al.
NATURE IMMUNOLOGY (2017)
Palmitate differentially regulates the polarization of differentiating and differentiated macrophages
Fangming Xiu et al.
IMMUNOLOGY (2016)
Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation
Stanley Ching-Cheng Huang et al.
IMMUNITY (2016)
Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells
Megan M. Robblee et al.
CELL REPORTS (2016)
Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
Anthony J. Covarrubias et al.
ELIFE (2016)
A guide to immunometabolism for immunologists
Luke A. J. O'Neill et al.
NATURE REVIEWS IMMUNOLOGY (2016)
Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling
Robert Caesar et al.
CELL METABOLISM (2015)
Concentration-Dependent Diversification Effects of Free Cholesterol Loading on Macrophage Viability and Polarization
Xiaoyang Xu et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2015)
The cell biology of fat expansion
Joseph M. Rutkowski et al.
JOURNAL OF CELL BIOLOGY (2015)
The Phosphoinositide 3-Kinase Signaling Pathway is Involved in the Control of Modified Low-Density Lipoprotein Uptake by Human Macrophages
Daryn R. Michael et al.
LIPIDS (2015)
Ceramides - Lipotoxic Inducers of Metabolic Disorders
Bhagirath Chaurasia et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)
Roles of Chemokines and Chemokine Receptors in Obesity-Associated Insulin Resistance and Nonalcoholic Fatty Liver Disease
Liang Xu et al.
BIOMOLECULES (2015)
Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
Yonit Lavin et al.
CELL (2014)
Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages
Mario Kratz et al.
CELL METABOLISM (2014)
Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation
Shinya U. Amano et al.
CELL METABOLISM (2014)
Metabolic Reprogramming of Macrophages GLUCOSE TRANSPORTER 1 (GLUT1)-MEDIATED GLUCOSE METABOLISM DRIVES A PROINFLAMMATORY PHENOTYPE
Alex J. Freemerman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Macrophage PTEN Regulates Expression and Secretion of Arginase I Modulating Innate and Adaptive Immune Responses
Emine Sahin et al.
JOURNAL OF IMMUNOLOGY (2014)
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity
Bhama Ramkhelawon et al.
NATURE MEDICINE (2014)
Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling
Lin Luo et al.
NATURE COMMUNICATIONS (2014)
Adipose Tissue Macrophages: Amicus adipem?
Justin I. Odegaard et al.
CELL METABOLISM (2013)
Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation
Xiaoyuan Xu et al.
CELL METABOLISM (2013)
Palmitate and Lipopolysaccharide Trigger Synergistic Ceramide Production in Primary Macrophages
Joel D. Schilling et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Adipose Tissue Foam Cells Are Present in Human Obesity
Hagit Shapiro et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)
Akt1-Mediated Regulation of Macrophage Polarization in a Murine Model of Staphylococcus aureus Pulmonary Infection
Feng Xu et al.
JOURNAL OF INFECTIOUS DISEASES (2013)
JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
Myoung Sook Han et al.
SCIENCE (2013)
Regulation of glucose transport by insulin: traffic control of GLUT4
Dara Leto et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization
Alicia Arranz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Macrophage-mediated inflammation in metabolic disease
Ajay Chawla et al.
NATURE REVIEWS IMMUNOLOGY (2011)
FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages
WuQiang Fan et al.
EMBO JOURNAL (2010)
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
Aliki Kosteli et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
The PI3K Pathway As Drug Target in Human Cancer
Kevin D. Courtney et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol
Xuewei Zhu et al.
JOURNAL OF LIPID RESEARCH (2010)
Myeloid Cell-Restricted Insulin Receptor Deficiency Protects Against Obesity-Induced Inflammation and Systemic Insulin Resistance
Jan Mauer et al.
PLOS GENETICS (2010)
Glucose Metabolism Is Required for Oxidized LDL-Induced Macrophage Survival Role of PI3K and Bcl-2 Family Proteins
Caryn L. Elsegood et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)
The Akt kinases Isoform specificity in metabolism and cancer
Eva Gonzalez et al.
CELL CYCLE (2009)
Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice
Savitha Subramanian et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)
Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals
David Patsouris et al.
CELL METABOLISM (2008)
Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress
Takafumi Senokuchi et al.
DIABETES (2008)
Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages
James P. Luyendyk et al.
JOURNAL OF IMMUNOLOGY (2008)
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B
Xiaoling Tang et al.
NATURE CELL BIOLOGY (2008)
Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development
Elisa Ciraolo et al.
SCIENCE SIGNALING (2008)
Metabolic endotoxemia initiates obesity and insulin resistance
Patrice D. Cani et al.
DIABETES (2007)
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Carey N. Lumeng et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
TLR4 links innate immunity and fatty acid-induced insulin resistance
Hang Shi et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development
Marieke Pennings et al.
FEBS LETTERS (2006)
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
Hajime Kanda et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
LC Foukas et al.
NATURE (2006)
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis
J Baumgartl et al.
CELL METABOLISM (2006)
Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions
S Han et al.
CELL METABOLISM (2006)
Critical nodes in signalling pathways: insights into insulin action
CM Taniguchi et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome
A Fortuno et al.
DIABETES (2006)
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
S Cinti et al.
JOURNAL OF LIPID RESEARCH (2005)
IKK-β links inflammation to obesity-induced insulin resistance
MC Arkan et al.
NATURE MEDICINE (2005)
Regulation of insulin action by ceramide - Dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B
S Stratford et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Insulin receptor substrate-2-dependent interleukin-4 signaling in macrophages is impaired in two models of type 2 diabetes mellitus
ME Hartman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formation
YC Fu et al.
BLOOD CELLS MOLECULES AND DISEASES (2004)
P50 alpha/p55 alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity
D Chen et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
CL Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
M Guha et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase
K Ueki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Insulin inhibits apoptosis of macrophage cell line, THP-1 cells, via phosphatidylinositol-3-kinase-dependent pathway
KT Iida et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)
Insulin signalling and the regulation of glucose and lipid metabolism
AR Saltiel et al.
NATURE (2001)
Insulin up-regulates tumor necrosis factor-α production in macrophages through an extracellular-regulated kinase-dependent pathway
KT Iida et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)