期刊
ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019
卷 6, 期 -, 页码 319-340出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-virology-092818-015748
关键词
lipids; membrane; metabolism; replication compartments; envelopment
类别
资金
- NIAID NIH HHS [R01 AI127518, R01 AI137514, R01 AI134980] Funding Source: Medline
- NIDDK NIH HHS [R01 DK102883] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007183] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI134980, R01AI137514, R01AI127518] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK102883] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007183] Funding Source: NIH RePORTER
Viruses manipulate cellular lipids and membranes at each stage of their life cycle. This includes lipid-receptor interactions, the fusion of viral envelopes with cellular membranes during endocytosis, the reorganization of cellular membranes to form replication compartments, and the envelopment and egress of virions. In addition to the physical interactions with cellular membranes, viruses have evolved to manipulate lipid signaling and metabolism to benefit their replication. This review summarizes the strategies that viruses use to manipulate lipids and membranes at each stage in the viral life cycle.
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