期刊
BIOCHEMISTRY
卷 55, 期 2, 页码 239-242出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biochem.5b01166
关键词
-
资金
- National Institutes of Health (NIH) [CA-28038, CA-168469, R01-GM079223]
- NIH [CA-75449]
Errors in epigenetic markings are associated with human diseases, including cancer. We have used molecular dynamics simulations of a nucleosome containing the 10S (+)-trans-anti-B[a]P-N-2-dG lesion, derived from the environmental pro-carcinogen benzo[a]pyrene, to elucidate the impact of the lesion on the structure and dynamics of a nearby histone N-terminal tail. Our results show that a lysine-containing part of this H2B tail that is subject to post-translational modification is engulfed by the enlarged DNA minor groove imposed by the lesion. The tail entrapment suggests that epigenetic markings could be hampered by this lesion, thereby impacting critical cellular functions, including transcription and repair.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据