期刊
ADVANCED SCIENCE
卷 6, 期 23, 页码 -出版社
WILEY
DOI: 10.1002/advs.201901551
关键词
Buchwald; DNA-encoded library; fluorosulfonate; palladium; Sonogashira; Suzuki
资金
- National Natural Science Foundation of China [21502114, 31500632]
- Science and Technology Commission of Shanghai Municipality [16DZ1910200]
- JPB Foundation [1097]
Using (hetero)aryl fluorosulfonates as versatile electrophiles, facile on-DNA cross-coupling reactions of Suzuki, Sonogashira, and Buchwald are reported here. Notably, all of these reactions show excellent functional group tolerance, mild reaction conditions (relative low temperature and open to air), rich heterocyclic coupling partners, and more importantly, DNA-compatibility. Thus, these new reactions based on efficient formation of C(sp(2))-C(sp(2)), C(sp(2))-C(sp), and C(sp(2))-N bonds are highly amenable to synthesis of DNA-encoded libraries with great molecular diversity.
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