期刊
ADVANCED SCIENCE
卷 6, 期 19, 页码 -出版社
WILEY
DOI: 10.1002/advs.201901211
关键词
2D nanosheets; biotite; combination cancer therapy; reactive oxygen species
资金
- U.S. METAvivor Early Career Investigator Award [2018A020560]
- Harvard Medical School (HMS)/Brigham and Women's Hospital (BWH) Department of Anesthesiology-Basic Scientist Grant [2420 BPA075]
- National Natural Science Foundation of China [81801826]
- Science, Technology & Innovation Commission of Shenzhen Municipality [JCYJ20180307153300735]
Biotite, also called black mica (BM), is a group of sheet silicate minerals with great potential in various fields. However, synthesis of high-quality BM nanosheets (NSs) remains a huge challenge. Here, an exfoliation approach is provided that combines calcination, n-butyllithium exchange and intercalation, and liquid exfoliating processes for the high-yield synthesis of ultrathin BM NSs. Due to the presence of MgO, Fe2O3, and FeO in these NSs, PEGylated BM can be engineered as an intelligent theranostic platform with the following unique features: i) Fe3+ can damage the tumor microenvironment (TME) through glutathione consumption and O-2 production; ii) Generated O-2 can be further catalyzed by MgO with oxygen vacancy to generate O-2(-); iii) The Fe2+-catalyzed Fenton reaction can produce OH by disproportionation reactions of H2O2 in the TME; iv) Reactions in (i) and (iii) circularly regenerate Fe2+ and Fe3+ for continuous consumption of glutathione and H2O2 and constant production of OH and O-2; v) The NSs can be triggered by a 650 nm laser to generate O-2(-) from O-2 as well as by an 808 nm laser to generate local hyperthermia; and vi) The fluorescent, photoacoustic, and photothermal imaging capabilities of the engineered NSs allow for multimodal imaging-guided breast cancer treatment.
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