期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 5, 期 9, 页码 4386-4392出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.9b00812
关键词
cell differentiation; piezoelectric stimulation; polypyrrole nanocones; poly(vinylidene fluoride)
资金
- National Natural Science Foundation of China [51772106, 51702104, 31771080]
- Natural Science Foundation of Guangdong Province [2016A030308014]
- Technological Projects of Guangzhou, China [201604020110]
- China Postdoctoral Science Foundation [2017M622641]
Imitating the physiological microenvironment of living cell and tissues opens new avenues of research into the application of electricity to medical therapies. In this study, dynamic piezoelectric stimulation is generated in a dynamic culture because of the piezoelectric effect of the poly(vinylidene fluoride)-polypyrrole (PVDF-PPy) electroactive composite. Combined with PPy nanocones, dynamic piezoelectric signals are effectively and continuously provided to cells. In the presence of dynamic piezoelectric stimulation and PPy nanocones, PPy-PVDF NS samples show promoted bone mesenchymal stem cell (BMSCs) adhesion, spreadin, and osteogenic differentiation. On the basis of the results of this study, PPy nanocones and dynamic piezoelectric stimulation can be administered to modulate cell behavior, paving the way for the exploration of cellular responses to dynamic electrical stimulation.
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