期刊
NANOMATERIALS
卷 9, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/nano9091219
关键词
mesoporous silica nanoparticles; regioselective functionalization; drug delivery; isothiocyanate
类别
资金
- Asociacion Duchenne Parent Project Espana
- Institut Quimic de Sarria (IQS)
A straightforward methodology for the synthesis of isothiocyanate-functionalized mesoporous silica nanoparticles (MSNs) by exposure of aminated MSNs to 1,1'-thiocarbonyldi-2(1H)-pyridone is reported. These nanoparticles are chemically stable, water tolerant, and readily react with primary amines without the formation of any by-product. This feature allows the easy modification of the surface of the nanoparticles for tuning their physical properties and the introduction of gatekeepers on the pore outlets. As a proof-of-concept, amino-isothiocyanate-functionalized MSNs have been used for the design of a nanocontainer able to release the drug Ataluren. The release profile of the drug can be easily fine-tuned with the careful choice of the capping amine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据