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Sulforaphane Activates Heat Shock Response and Enhances Proteasome Activity through Up-regulation of Hsp27
Nanqin Gan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Effect of proteasome inhibition by MG-132 on HSP27 oligomerization, phosphorylation, and aggresome formation in the OLN-93 oligodendroglia cell line
Sandra Bolhuis et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Phosphorylation Dynamics Regulate Hsp27-Mediated Rescue of Neuronal Plasticity Deficits in Tau Transgenic Mice
Jose F. Abisambra et al.
JOURNAL OF NEUROSCIENCE (2010)
Evidence in Favor of Braak Staging of Parkinson's Disease
Dennis W. Dickson et al.
MOVEMENT DISORDERS (2010)
Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers
Stefan Jehle et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
αB Crystallin Is Apically Secreted within Exosomes by Polarized Human Retinal Pigment Epithelium and Provides Neuroprotection to Adjacent Cells
Parameswaran G. Sreekumar et al.
PLOS ONE (2010)
Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation
Amy L. Robertson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Quaternary dynamics and plasticity underlie small heat shock protein chaperone function
Florian Stengel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function
Arthur Laganowsky et al.
PROTEIN SCIENCE (2010)
Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
Evan T. Powers et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
Structure and Mechanism of Protein Stability Sensors: Chaperone Activity of Small Heat Shock Proteins
Hassane S. Mchaourab et al.
BIOCHEMISTRY (2009)
HSPB7 is a SC35 speckle resident small heat shock protein
Michel J. Vos et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)
Heterooligomeric complexes formed by human small heat shock proteins HspB1 (Hsp27) and HspB6 (Hsp20)
Olesya V. Bukach et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2009)
Guidelines for the nomenclature of the human heat shock proteins
Harm H. Kampinga et al.
CELL STRESS & CHAPERONES (2009)
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
Martin Gamerdinger et al.
EMBO JOURNAL (2009)
Alpha crystallin: The quest for a homogeneous quaternary structure
Joseph Horwitz
EXPERIMENTAL EYE RESEARCH (2009)
Binding of Hsp90 to Tau Promotes a Conformational Change and Aggregation of Tau Protein
Elena Tortosa et al.
JOURNAL OF ALZHEIMERS DISEASE (2009)
HspB8 Participates in Protein Quality Control by a Non-chaperone-like Mechanism That Requires eIF2α Phosphorylation
Serena Carra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Phosphorylation Dependence of Hsp27 Multimeric Size and Molecular Chaperone Function
David Hayes et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The Small Heat-Shock Proteins HSPB2 and HSPB3 Form Well-defined Heterooligomers in a Unique 3 to 1 Subunit Ratio
John den Engelsman et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Crystal Structures of α-Crystallin Domain Dimers of αB-Crystallin and Hsp20
C. Bagneris et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Substrate binding site flexibility of the small heat shock protein molecular chaperones
Nomalie Jaya et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The eye lens chaperone α-crystallin forms defined globular assemblies
Jirka Peschek et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
HspB8 and Bag3 - A new chaperone complex targeting misfolded proteins to macroautophagy
Serena Carra et al.
AUTOPHAGY (2008)
Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A
Katey Rayner et al.
CIRCULATION RESEARCH (2008)
Over-expression of Hsp27 does not influence disease in the mutant SOD1G93A mouse model of amyotrophic lateral sclerosis
Jyothsna Krishnan et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Small heat shock proteins Hsp27 or αB-crystallin and the protein components of neurofibrillary tangles:: Tau and neurofilaments
Cecilia Bjorkdahl et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2008)
Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression
Paul S. Sharp et al.
NEUROBIOLOGY OF DISEASE (2008)
Expression of the small heat shock protein family in the mouse CNS: differential anatomical and biochemical compartmentalization
S. Quraishe et al.
NEUROSCIENCE (2008)
Amyloid Oligomer Conformation in a Group of Natively Folded Proteins
Yuji Yoshiike et al.
PLOS ONE (2008)
Proteasome activation during cardiac hypertrophy by the chaperone H11 Kinase/Hsp22
Nadia Hedhli et al.
CARDIOVASCULAR RESEARCH (2008)
Hsp27 (HspB1) and αB-crystallin (HspB5) as therapeutic targets
Andr-Patrick Arrigo et al.
FEBS LETTERS (2007)
Inhibitors of the heat shock response: Biology and pharmacology
Marissa V. Powers et al.
FEBS LETTERS (2007)
Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation
Alexandra Zourlidou et al.
HUMAN MOLECULAR GENETICS (2007)
Recruitment of phosphorylated small heat shock protein Hsp27 to nuclear speckles without stress
A. L. Bryantsev et al.
EXPERIMENTAL CELL RESEARCH (2007)
Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy
E. Schmitt et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2007)
Mimicking phosphorylation of alpha B-crystallin affects its chaperone activity
Heath Ecroyd et al.
BIOCHEMICAL JOURNAL (2007)
Cryoelectron microscopy and EPR analysis of engineered symmetric and polydisperse Hsp16.5 assemblies reveals determinants of polydispersity and substrate binding
Jian Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
αB-crystallin competes with Alzheimer's disease β-amyloid peptide for peptide-peptide interactions and induces oxidation of Abeta-Met35
Saravanakumar Narayanan et al.
FEBS LETTERS (2006)
Small heat shock proteins differentially affect Aβ aggregation and toxicity
Sungmun Lee et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
HSP27 favors ubiquitination and proteasomal degradation of p27Kip1 and helps S-phase re-entry in stressed cells
Arnaud Parcellier et al.
FASEB JOURNAL (2006)
Small heat shock proteins inhibit amyloid-β protein aggregation and cerebrovascular amyloid-β protein toxicity
Micha M. M. Wilhelmus et al.
BRAIN RESEARCH (2006)
Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer's disease brains
MMM Wilhelmus et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2006)
Self-association and chaperone activity of Hsp27 are thermally activated
B Lelj-Garolla et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Small heat shock protein HspB8:: its distribution in Alzheimer's disease brains and its inhibition of amyloid-β protein aggregation and cerebrovascular amyloid-β toxicity
MMM Wilhelmus et al.
ACTA NEUROPATHOLOGICA (2006)
Interactions of HSP22 (HSPB8) with HSP20, αB-crystallin, and HSPB3
JM Fontaine et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Some like it hot: the structure and function of small heat-shock proteins
M Haslbeck et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Heat shock response modulators as therapeutic tools for diseases of protein conformation
SD Westerheide et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Induction of heat shock proteins in B-cell exosomes
A Clayton et al.
JOURNAL OF CELL SCIENCE (2005)
Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms
YL Zhang et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2005)
Upregulation of heat shock protein expression by proteasome inhibition: An antiapoptotic mechanism in the lens
N Awasthi et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2005)
Mechanism of chaperone function in small heat shock proteins - Dissociation of the Hsp27 oligomer is required for recognition and binding of destabilized T4 lysozyme
R Shashidharamurthy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival
H Shimura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Analysis of the regulation of the molecular chaperone Hsp26 by temperature-induced dissociation - The N-terminal domain is important for oligomer assembly and the binding of unfolding proteins
T Stromer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Roles for αB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model
LE Morrison et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)
Interaction of human HSP22 (HSPB8) with other small heat shock proteins
XK Sun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Identification of a redox-regulated chaperone network
JH Hoffmann et al.
EMBO JOURNAL (2004)
Development of a human light chain variable domain (VL) intracellular antibody specific for the amino terminus of huntingtin via yeast surface display
DW Colby et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Interaction of the molecular chaperone αB-crystallin with α-synuclein:: Effects on amyloid fibril formation and chaperone activity
A Rekas et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Mammalian Hsp22 is a heat-inducible small heat-shock protein with chaperone-like activity
TK Chowdary et al.
BIOCHEMICAL JOURNAL (2004)
Evolutionary diversity of vertebrate small heat shock proteins
E Franck et al.
JOURNAL OF MOLECULAR EVOLUTION (2004)
Expression of the small heat-shock protein alpha B-crystallin in tauopathies with glial pathology
DV Dabir et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Transglutaminase catalyzes differential crosslinking of small heat shock proteins and amyloid-β
S Boros et al.
FEBS LETTERS (2004)
The heat-shock protein receptors: some answers and more questions
RJ Binder et al.
TISSUE ANTIGENS (2004)
Forced expression of the H11 heat shock protein can be regulated by DNA methylation and trigger apoptosis in human cells
MD Gober et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Enhancement of chaperone function of α-crystallin by methylglyoxal modification
RH Nagaraj et al.
BIOCHEMISTRY (2003)
HSP27 is a ubiquitin-binding protein involved in I-κBα proteasomal degradation
A Parcellier et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1
J Hargitai et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Parkinson's syndrome associated with neurofibrillary degeneration and tau pathologic findings
AJ Lees
MOVEMENT DISORDERS (2003)
Upregulation of HSP27 in a transgenic model of ALS
V Vleminckx et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2002)
S-thiolation of HSP27 regulates its multimeric aggregate size independently of phosphorylation
P Eaton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin
A Wyttenbach et al.
HUMAN MOLECULAR GENETICS (2002)
Crystal structure and assembly of a eukaryotic small heat shock protein
RLM van Montfort et al.
NATURE STRUCTURAL BIOLOGY (2001)
The molecular chaperone, α-crystallin, inhibits amyloid formation by apolipoprotein C-II
DM Hatters et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
A novel quaternary structure of the dimeric α-crystallin domain with chaperone-like activity
IK Feil et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Phosphorylation-induced Change of the Oligomerization state of αB-crystallin
K Ito et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Interaction between β-amyloid and lens αβ-crystallin
JJN Liang
FEBS LETTERS (2000)
Mouse Hsp25, a small heat shock protein - The role of its C-terminal extension in oligomerization and chaperone action
RA Lindner et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)
The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome
J Lüders et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Small heat-shock protein structures reveal a continuum from symmetric to variable assemblies
DA Haley et al.
JOURNAL OF MOLECULAR BIOLOGY (2000)
Subunit exchange of small heat shock proteins -: Analysis of oligomer formation of αA-crystallin and Hsp27 by fluorescence resonance energy transfer and site-directed truncations
MP Bova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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