期刊
FRONTIERS IN NEUROSCIENCE
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2019.00869
关键词
neuropeptide Y; neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; neuroimmune disorders; Guillain-Barre syndrome
资金
- First Hospital of Jilin University, Changchun
- China General Program of the National Natural Science Foundation of China [81771299, 81471216]
- Young Scholars Program of The First Hospital of Jilin University [JDYY82017029]
- Swedish Research Council [2015-03005]
- Swedish Research Council [2015-03005] Funding Source: Swedish Research Council
Neuropeptide Y (NPY) is a neurotransmitter or neuromodulator that mainly exists in the nervous system. It plays a neuroprotective role in organisms and widely participates in the regulation of various physiological processes in vivo. Studies in both humans and animal models have been revealed that NPY levels are altered in some neurodegenerative and neuroimmune disorders. NPY plays various roles in these diseases, such as exerting a neuroprotective effect, increasing trophic support, decreasing excitotoxicity, regulating calcium homeostasis, and attenuating neuroinflammation. In this review, we will focus on the roles of NPY in the pathological mechanisms of neurodegenerative and neuroimmune diseases, highlighting NPY as a potential therapeutic target in these diseases.
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