期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 44, 期 -, 页码 1058-1065出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20160080
关键词
alternative splicing; heterogeneous nuclear ribonucleoprotein (hnRNP); Matrin3; polypyrimidine tract binding protein; PTB; RNA
资金
- Biotechnology and Biological Sciences Research Council [BB/H004203/1]
- Wellcome Trust [092900]
- Boehringer Ingelheim Fond
- Medical Research Council [MR/M026302/1]
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais [MR/M026302/1]
- National Health and Medical Research Council CJ Martin Fellowship [APP1072476]
- BBSRC [BB/H004203/1] Funding Source: UKRI
- MRC [MR/M026302/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/H004203/1] Funding Source: researchfish
- Medical Research Council [MR/M026302/1] Funding Source: researchfish
Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm. PTBP1 has four RNA binding domains of the RNA recognition motif (RRM) family, each of which can bind to pyrimidine motifs. In addition, RRM2 can interact via its dorsal surface with proteins containing short peptide ligands known as PTB RRM2 interacting (PRI) motifs, originally found in the protein Raver1. Here we review our recent progress in understanding the interactions of PTB with RNA and with various proteins containing PRI ligands.
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