期刊
BIOCHEMICAL PHARMACOLOGY
卷 115, 期 -, 页码 77-84出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2016.06.018
关键词
3,3 '-Diindolylmethane; Gastric cancer; miR-30e; ATG5; Autophagy
资金
- Natural Science Foundation of China [81502800]
- China Postdoctoral Science Foundation [2015M571694]
- Jiangsu Planned Projects for Postdoctoral Research Funds [1402169C]
- Research Foundation for Advanced Talents of Jiangsu University [14JDG044]
3,3'-Diindolylmethane (DIM), a class of relatively non-toxic indole derivatives from cruciferous vegetables, has been reported as a promising anticancer phytochemical, but the underlying molecular mechanism is not completely elucidated. In the present study we report a novel regulation of autophagy by DIM in human gastric cancer cells. We found that DIM dose-dependently inhibited the growth of gastric cancer cells in vitro and in vivo. Moreover, ATG5 and LC3 were activated by DIM in gastric cancer cells. Furthermore, miR-30e was down-regulated by DIM and miR-30e targeted the 3'-UTR of ATG5 to inhibit its translation. Overall, these results suggest that DIM may through the miR-30e-ATG5 modulating autophagy inhibit the proliferation of gastric cancer cells. (C) 2016 Elsevier Inc. All rights reserved.
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