期刊
MICROMACHINES
卷 10, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/mi10090593
关键词
microfluidics; red blood cells (RBCs); microfabrication; polymers; separation and sorting techniques
类别
资金
- FCT [UID/EEA/04436/2019, UID/EMS/04077/2019, UID/EMS/00532/2019]
- NORTE 2020 Portugal Regional Operational Programme, under PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund [NORTE-01-0145-FEDER-028178, NORTE-01-0145-FEDER-029394, NORTE-01-0145-FEDER-030171]
- Fundacao para a Ciencia e Tecnologia (FCT), IP
- Fundação para a Ciência e a Tecnologia [UID/EMS/00532/2019] Funding Source: FCT
Since the first microfluidic device was developed more than three decades ago, microfluidics is seen as a technology that exhibits unique features to provide a significant change in the way that modern biology is performed. Blood and blood cells are recognized as important biomarkers of many diseases. Taken advantage of microfluidics assets, changes on blood cell physicochemical properties can be used for fast and accurate clinical diagnosis. In this review, an overview of the microfabrication techniques is given, especially for biomedical applications, as well as a synopsis of some design considerations regarding microfluidic devices. The blood cells separation and sorting techniques were also reviewed, highlighting the main achievements and breakthroughs in the last decades.
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