期刊
INFECTIOUS AGENTS AND CANCER
卷 14, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13027-019-0239-4
关键词
Porphyromonasgingivalis; Periodontitis; Gastrointestinal cancer; esophageal cancer; Pancreatic cancer
资金
- Taihe Hospital [2012QD09]
- 2016 Joint Diagnostic Medicine Research Project of Taihe Hospital [2016JZ02]
Bacterial infection may be involved in the entire process of tissue carcinogenesis by directly or indirectly affecting the occurrence and development of tumors. Porphyromonas gingivalis (P.gingivalis) is an important pathogen causing periodontitis. Periodontitis may promote the occurrence of various tumors. Gastrointestinal tumors are common malignant tumors with high morbidity, high mortality, and low early diagnosis rate. With the rapid development of molecularbiotechnology, the role of P.gingivalis in digestive tract tumors has been increasingly explored. This article reviews the correlation between P.gingivalis and gastrointestinal cancer and the pathogenesis of the latter. The relationship among P.gingivalis, periodontal disease, and digestive tract tumors must be clarifiedthrough a multi-center, prospective, large-scale study.
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