Label-Efficient Breast Cancer Histopathological Image Classification

The automatic classification of breast cancer histopathological images has great significance in computer-aided diagnosis. Recently, deep learning via neural networks has enabled pattern detection and prediction using large, labeled datasets; whereas, collecting and annotating sufficient histological data using professional pathologists is time consuming, tedious, and extremely expensive. In the proposed paper, a deep active learning framework is designed and implemented for classification of breast cancer histopathological images, with the goal of maximizing the learning accuracy from very limited labeling. This method involves manual annotation of the most valuable unlabeled samples, which are then integrated into the training set. The model is then iteratively updated with an increasing training set. Here, two selection strategies are discussed for the proposed deep active learning framework: An entropy-based strategy and a confidence-boosting strategy. The proposed method has been validated using a publicly available breast cancer histopathological image dataset, wherein each image patch is binarily classified as benign or malignant. The experimental results demonstrate that, compared with a random selection, our proposed framework can reduce annotation costs up to 66.67%, with higher accuracy and less expensive annotation than standard query strategy.