期刊
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
卷 10, 期 3, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a037093
关键词
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资金
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [240245 660-SFB 1129, 112927078-TRR 83, 272983813-TRR 179]
- European Molecular Biology Organization (EMBO) Long-Term Fellowship [ALTF 466-2016]
Replication and amplification of the viral genome is a key process for all viruses. For hepatitis C virus (HCV), a positive-strand RNA virus, amplification of the viral genome requires the synthesis of a negative-sense RNA template, which is in turn used for the production of new genomic RNA. This process is governed by numerous proteins, both host and viral, as well as distinct lipids and specific RNA elements within the positive- and negative-strand RNAs. Moreover, this process requires specific changes to host cell ultrastructure to create micro-environments conducive to viral replication. This review will focus on describing the processes and factors involved in facilitating or regulating HCV genome replication.
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